개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 159 - 168 (10page)
이용수
초록· 키워드
오류제보하기
Background: Radiotherapy is one of the most important modalities in cancer treatment; however, normal tissue damage is a serious concern. Drug development for the protection or reduction of normal tissue damage is therefore a clinical issue. Herein, we evaluated the protective properties of Panax ginseng Meyer and its corresponding mechanisms.
Methods: C56BL/6 mice were orally pretreated with P. ginseng water extract (PGE; 25 mg/kg, 50 mg/kg, or 100 mg/kg) or intraperitoneally injected melatonin (20 mg/kg) for 4 d consecutively, then exposed to 15-Gy X-ray radiation 1 h after the last administration. After 10 d of irradiation, the biological properties of hematoxicity, fat accumulation, histopathology, oxidative stress, antioxidant activity, proinflammatory cytokines, and apoptosis signals were examined in the hepatic tissue.
Results: The irradiation markedly induced myelosuppression as determined by hematological analysis of the peripheral blood. Steatohepatitis was induced by X-ray irradiations, whereas pretreatment with PGE significantly attenuated it. Oxidative stress was drastically increased, whereas antioxidant components were depleted by irradiation. Irradiation also notably increased serum liver enzymes and hepatic protein levels of pro-inflammatory cytokines. Those alterations were markedly normalized by pretreatment with PGE. The degree of irradiation-induced hepatic tissue apoptosis was also attenuated by pretreatment with PGE, which was evidenced by a terminal deoxynucleotidyl transferase 20-deoxyuridine 50-triphosphate nick-end labeling assay, western blotting, and gene expressions analysis, particularly of apoptotic molecules.
Conclusion: We suggest that PGE could be applicable for use against radiation-induced liver injury, and its corresponding mechanisms involve the modulation of oxidative stress, inflammatory reactions, and apoptosis.
Methods: C56BL/6 mice were orally pretreated with P. ginseng water extract (PGE; 25 mg/kg, 50 mg/kg, or 100 mg/kg) or intraperitoneally injected melatonin (20 mg/kg) for 4 d consecutively, then exposed to 15-Gy X-ray radiation 1 h after the last administration. After 10 d of irradiation, the biological properties of hematoxicity, fat accumulation, histopathology, oxidative stress, antioxidant activity, proinflammatory cytokines, and apoptosis signals were examined in the hepatic tissue.
Results: The irradiation markedly induced myelosuppression as determined by hematological analysis of the peripheral blood. Steatohepatitis was induced by X-ray irradiations, whereas pretreatment with PGE significantly attenuated it. Oxidative stress was drastically increased, whereas antioxidant components were depleted by irradiation. Irradiation also notably increased serum liver enzymes and hepatic protein levels of pro-inflammatory cytokines. Those alterations were markedly normalized by pretreatment with PGE. The degree of irradiation-induced hepatic tissue apoptosis was also attenuated by pretreatment with PGE, which was evidenced by a terminal deoxynucleotidyl transferase 20-deoxyuridine 50-triphosphate nick-end labeling assay, western blotting, and gene expressions analysis, particularly of apoptotic molecules.
Conclusion: We suggest that PGE could be applicable for use against radiation-induced liver injury, and its corresponding mechanisms involve the modulation of oxidative stress, inflammatory reactions, and apoptosis.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (55)
참고문헌 신청
[학술지(정기간행물)] - Ferlay J / 2015 / Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012 / Int J Cancer 136 : E359 ~ E386
[학술지(정기간행물)] - Gomaa AI / 2008 / Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis / World J Gastroenterol 14 : 4300 ~ 4308
[학술지(정기간행물)] - Ferro A / 2014 / Worldwide trends in gastric cancer mortality (1980e 2011), with predictions to 2015, and incidence by subtype / Eur J Cancer 50 : 1330 ~ 1344
[학술지(정기간행물)] - Kim JL / 2014 / A single measure of cancer burden combiningincidence with mortality rates for worldwide application / Asian Pac J Cancer Prev 15 : 433 ~ 439
[학술지(정기간행물)] - Delanian S / 2007 / Current management for late normal tissue injury : radiation-induced fibrosis and necrosis / Semin Radiat Oncol 17 : 99 ~ 107
[학술지(정기간행물)] - Gomaa AI / 2008 / Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis / World J Gastroenterol 14 : 4300 ~ 4308
[학술지(정기간행물)] - Ferro A / 2014 / Worldwide trends in gastric cancer mortality (1980e 2011), with predictions to 2015, and incidence by subtype / Eur J Cancer 50 : 1330 ~ 1344
[학술지(정기간행물)] - Kim JL / 2014 / A single measure of cancer burden combiningincidence with mortality rates for worldwide application / Asian Pac J Cancer Prev 15 : 433 ~ 439
[학술지(정기간행물)] - Delanian S / 2007 / Current management for late normal tissue injury : radiation-induced fibrosis and necrosis / Semin Radiat Oncol 17 : 99 ~ 107
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Low-dose-rate irradiation induces the expression changes of apoptosis-associated genes
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Implications of red Panax ginseng in oxidative stress associated chronic diseases
Journal of Ginseng Research
2017 .04
-
Effects of Panax ginseng and ginsenosides on oxidative stress and cardiovascular diseases: pharmacological and therapeutic roles
Journal of Ginseng Research
2022 .01
-
Korean Red Ginseng and Korean black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress
Journal of Ginseng Research
2020 .03
-
Steamed ginger extract ameliorates alcohol-induced liver injury in mice via modulation of inflammatory response and oxidative stress
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Siderophore-producing rhizobacteria reduce heavy metal-induced oxidative stress in Panax ginseng Meyer
Journal of Ginseng Research
2021 .03
-
Pectinase-treated Panax ginseng ameliorates hydrogen peroxide-induced oxidative stress in GC-2 sperm cells and modulates testicular gene expression in aged rats
Journal of Ginseng Research
2016 .04
-
Characterization of Korean Red Ginseng (Panax ginseng Meyer) : History, preparation method, and chemical composition
Journal of Ginseng Research
2015 .10
-
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Journal of Yeungnam Medical Science
2023 .04
-
Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Protective role of β-carotene in heat-induced apoptosis and oxidative stress in mice testes
한국실험동물학회 학술발표대회 논문집
2015 .02
-
만성 저온 스트레스 동물모델에서의 황련(黃連)의 항염증 효능 연구
대한본초학회지(본초분과학회지)
2018 .01
-
Korean Red Ginseng (Panax ginseng Meyer) with enriched Rg3 ameliorates chronic intermittent heat stress-induced testicular damage in rats via multifunctional approach
Journal of Ginseng Research
2019 .01
-
Rh2-enriched Korean Ginseng Ameliorates Chronic Fatigue in a Forced Exercise mouse model
대한한의학회지
2016 .06
-
Ameliorative effect of black ginseng extract against oxidative stress-induced cellular damages in mouse hepatocytes
Journal of Ginseng Research
2019 .04
-
Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy
Journal of dental anesthesia and pain medicine
2017 .01
-
Interleukin-10 protects ureteral obstruction-induced renal fibrosis by attenuating oxidative stress and apoptosis
대한체질인류학회 학술대회 연제 초록
2019 .05
-
Treatment outcome of hepatic re-irradiation in patients with hepatocellular carcinoma
Radiation oncology journal : ROJ
2015 .01
-
Sargassum horneri ethanol extract attenuates the PM-induced oxidative stress and DNA damage in liver of asthma mice model
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice
Journal of Pharmacopuncture
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-524-001598810