지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.8
- 수록면
- 16 - 27 (12page)
이용수
초록· 키워드
오류제보하기
Viperin is a multifunctional protein that was first identified in human primary macrophages treated with interferon-γ and in human fibroblasts infected with human cytomegalovirus. This protein plays a role as an anti-viral protein and a regulator of cell signaling pathways or cellular metabolism when induced in a variety of cells such as fibroblasts, hepatocytes and immune cells including T cells and dendritic cells. However, the role of viperin in macrophages is unknown. Here, we show that viperin is basally expressed in murine bone marrow cells including monocytes. Its expression is maintained in bone marrow monocyte-derived macrophages (BMDMs) depending on macrophage colony-stimulating factor (M-CSF) treatment but not on granulocyte-macrophage colony-stimulating factor (GM-CSF) treatment. In wild type (WT) and viperin knockout (KO) BMDMs differentiated with M-CSF or G-MCSF, there are little differences at the gene expression levels of M1 and M2 macrophage markers such as inducible nitric oxide synthase (iNOS) and arginase-1, and cytokines such as IL-6 and IL-10, indicating that viperin expression in BMDMs does not affect the basal gene expression of macrophage markers and cytokines. However, when BMDMs are completely polarized, the levels of expression of macrophage markers and secretion of cytokines in viperin KO M1 and M2 macrophages are significantly higher than those in WT M1 and M2 macrophages. The data suggest that viperin plays a role as a regulator in polarization of macrophages and secretion of M1 and M2 cytokines.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (32)
참고문헌 신청
Mosser DM / 2008 / Exploring the full spectrum of macrophage activation / Nat Rev Immunol 8:958~969
Gordon S / 2010 / Alternative activation of macrophages: mechanism and functions / Immunity 32:593~604
Liu YC / 2014 / Macrophage polarization in inflammatory diseases / Int J Biol Sci 10:520~529
Wynn TA / 2013 / Macrophage biology in development, homeostasis and disease / Nature 496:445~455
Malyshev I / 2015 / Current concept and update of the macrophage plasticity concept: intracellular mechanisms of reprogramming and m3 macrophage switch phenotype / BioMed Res Int 2015:341308
Gordon S / 2010 / Alternative activation of macrophages: mechanism and functions / Immunity 32:593~604
Liu YC / 2014 / Macrophage polarization in inflammatory diseases / Int J Biol Sci 10:520~529
Wynn TA / 2013 / Macrophage biology in development, homeostasis and disease / Nature 496:445~455
Malyshev I / 2015 / Current concept and update of the macrophage plasticity concept: intracellular mechanisms of reprogramming and m3 macrophage switch phenotype / BioMed Res Int 2015:341308
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation of Macrophage Activation and Differentiation in Atherosclerosis
지질·동맥경화학회지
2021 .09
-
Differential Activation of Macrophages Based on Their Environment in Advanced Age
전남의대학술지
2020 .01
-
SCAP deficiency in macrophages exacerbates inflammation by promoting M1 macrophage polarization
한국실험동물학회 학술발표대회 논문집
2020 .02
-
KLF10 as a regulator of macrophage activation and inflammation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Triglyceride Regulates the Expression of M1 and M2 Macrophage-specific Markers in THP-1 Monocytes
대한의생명과학회지
2016 .12
-
Potential Role of Heme Oxygenase-1 in the Resolution of Experimentally Induced Colitis through Regulation of Macrophage Polarization
Gut and Liver
2022 .03
-
Application of ex-vivo generated macrophages as potential cell therapy
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Melatonin significantly down-regulates long non-coding RNA Cox2 in M1 macrophages stimulated with LPS
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Pro-Inflammatory Role of S1P<sub>3</sub> in Macrophages
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages
Immune Network
2021 .04
-
M2-like macrophages transplantation protects against the doxorubicin-induced heart failure via mitochondrial transfer
생체재료학회지
2022 .06
-
Role of Osteal Macrophages in Bone Metabolism
Journal of Pathology and Translational Medicine
2015 .01
-
Cyclophilin A protects preterm birth by modulating macrophage polarization in a mouse model of inflammation-induced preterm birth
한국실험동물학회 학술발표대회 논문집
2021 .07
-
반하 추출물의 종양연관대식세포 조절을 통한 암세포 이동능 저해 효과
동의생리병리학회지
2022 .02
-
Polarization of M2 Macrophages by Interaction between Prostate Cancer Cells Treated with Trichomonas vaginalis and Adipocytes
Parasites, Hosts and Diseases
2020 .06
-
The regulatory function of Hes1 in metabolic disease related macrophage
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Comprehensive Lipid Profiling Recapitulates Enhanced Lipolysis and Fatty Acid Metabolism in Intimal Foamy Macrophages From Murine Atherosclerotic Aorta
Immune Network
2023 .08
-
Involvement of Macrophages in Proliferation of Prostate Cancer Cells Infected with Trichomonas vaginalis
Parasites, Hosts and Diseases
2021 .12
-
Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types
Immune Network
2019 .10
-
Ethyl Acetate Fraction of Adenophora triphylla var. japonica Inhibits Migration of Lewis Lung Carcinoma by Suppressing Macrophage Polarization toward an M2 Phenotype
Journal of Pharmacopuncture
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-517-003392079