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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 79 - 83 (5page)
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This study compared serum concentrations of suppression of tumorigenicity 2 (ST2) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between healthy and heartworm- infected dogs. Eighteen heartworm-infected dogs and five healthy dogs were included in the study. Dogs were diagnosed and categorized by history, clinical signs, and blood assay, thoracic radiography, echocardiography, and com-mercial ELISA kit results. Serum samples were sent to the IDEXX reference laboratory for NT-proBNP measurement. ST2 was examined by using a canine interleukin 33 receptor ELISA kit with the quantita-tive sandwich ELISA method. The severely infected group showed significant elevation of NT-proBNP concentration over those of the control (P=0.03) and mildly infected (P=0.04) group. There were no significant difference in ST2 concentrations among the three groups. The usefulness of NT-proBNP as a cardiac biomarker in dogs with severe heartworm disease was confirmed by the results of this study. Further investigations to assess ST2 as a cardiac biomarker are warranted.
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등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
American heartworm society / 2014 / Guidelines for the diagnosis, prevention and management of heartworm (Dirofilaria immitis) infection in dogs
Atkinson AJ / 2001 / Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework / Clin Pharmacol Ther 69:89~95
Bayes-Genis A / 2012 / Combined use of high‐sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure / Eur J Heart Fail 14:32~38
Boswood A / 2009 / Biomarkers in cardiovascular disease: Beyond natriuretic peptides / J Vet Cardiol 11:S23~S32
Braunwald E / 2008 / Biomarkers in heart failure / N Engl J Med 358:2148~2159
Atkinson AJ / 2001 / Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework / Clin Pharmacol Ther 69:89~95
Bayes-Genis A / 2012 / Combined use of high‐sensitivity ST2 and NTproBNP to improve the prediction of death in heart failure / Eur J Heart Fail 14:32~38
Boswood A / 2009 / Biomarkers in cardiovascular disease: Beyond natriuretic peptides / J Vet Cardiol 11:S23~S32
Braunwald E / 2008 / Biomarkers in heart failure / N Engl J Med 358:2148~2159
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