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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 477 - 486 (10page)
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Background/Aims: Radiofrequency ablation (RFA) is one of the most frequently applied curative treatments in patients with a single small hepatocellular carcinoma (HCC). However, the clinical significance of and risk factors for early massive recurrence after RFA—a dreadful event limiting further curative treatment—have not been fully evaluated.
Methods: In total, 438 patients with a single HCC of size ≤3 cm who underwent percutaneous RFA as an initial treatment between 2006 and 2009 were included. Baseline patient characteristics, overall survival, predictive factors, and recurrence after RFA were evaluated. In addition, the incidence, impact on survival, and predictive factors of early massive recurrence, and initial recurrence beyond the Milan criteria within 2 years were also investigated.
Results: During the median follow-up of 68.4 months, recurrent HCC was confirmed in 302 (68.9%) patients, with early massive recurrence in 27 patients (6.2%). The 1-, 3-, and 5-year overall survival rates were 95.4%, 84.7%, and 81.8%, respectively, in patients with no recurrence, 99.6%, 86.4%, and 70.1% in patients with recurrence within the Milan criteria or late recurrence, and 92.6%, 46.5%, and 0.05% in patients with early massive recurrence. Multivariable analysis identified older age, Child-Pugh score B or C, and early massive recurrence as predictive of poor overall survival. A tumor size of ≥2 cm and tumor location adjacent to the colon were independent risk factors predictive of early massive recurrence.
Conclusions: Early massive recurrence is independently predictive of poor overall survival after RFA in patients with a single small HCC. Tumors sized ≥2 cm and located adjacent to the colon appear to be independent risk factors for early massive recurrence. (Clin Mol Hepatol 2016;22:477-486)
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참고문헌 (31)
참고문헌 신청
Kim YS / 2014 / Ablation of hepatocellular carcinoma / Best Pract Res Clin Gastroenterol 28:897~908
European Association For The Study Of The Liver, European Organisation For Research And Treatment Of Cancer / 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / Hepatology 53:1020~1022
Korean Liver Cancer Study Group, National Cancer Center / 2009 / Practice guidelines for management of hepatocellular carcinoma 2009 / Korean J Hepatol 15:391~423
Yu SJ. / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world: 2010-2016 / Clin Mol Hepatol 22:7~17
European Association For The Study Of The Liver, European Organisation For Research And Treatment Of Cancer / 2012 / EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma / J Hepatol 56:908~943
Bruix J / 2011 / American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma: an update / Hepatology 53:1020~1022
Korean Liver Cancer Study Group, National Cancer Center / 2009 / Practice guidelines for management of hepatocellular carcinoma 2009 / Korean J Hepatol 15:391~423
Yu SJ. / 2016 / A concise review of updated guidelines regarding the management of hepatocellular carcinoma around the world: 2010-2016 / Clin Mol Hepatol 22:7~17
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