지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 79 - 86 (8page)
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초록· 키워드
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Objective: To investigate individual pretreatment serum human chorionic gonadotropin (hCG) cutoff value for medical treatment success with single-dose and multi-dose regimen of methotrexate in tubal ectopic pregnancy.
Methods: Eighty-five women who received methotrexate for the treatment of tubal ectopic pregnancy during 2003 to 2015 were selected. Fifty-three women received a single-dose regimen and 32 women received a multi-dose regimen. Medical treatment failure was defined as necessity of surgical treatment. The medical treatment success rate was estimated in both regimens and the pretreatment serum hCG titer to predict the success was assessed by receiver operating characteristics curve analysis.
Results: Pretreatment clinical and laboratory parameters were similar between group of single-dose regimen and multi-dose regimen. Treatment success rate was 64.2% in the single-dose regimen group and 71.9% in the multi-dose regimen group (P>0.05). Pretreatment serum hCG titer was an independent prognostic factor for treatment success in each regimen. Serum hCG cutoff value to predict the treatment success was 3,026 IU/L in single-dose regimen group and 3,711 IU/L in multi-dose regimen group.
Conclusion: We recommend use of single-dose regimen when pretreatment serum hCG <3,026 IU/L but multi-dose regimen may be favored when initial serum hCG level between 3,026 and 3,711 IU/L.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Alleyassin A / 2006 / Comparison of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate:a prospecti
Barnhart KT / 2003 / The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens / Obstet Gynecol 101 : 778 ~ 784
Centers for Disease Control and Prevention / 2012 / Ectopic pregnancy mortality: Florida, 2009-2010 / MMWR Morb Mortal Wkly Rep 61 : 106 ~ 109
Gamzu R / 2002 / Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations / Fertil Steril 7
Guvendag Guven ES / 2010 / Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study / Acta Obstet Gy
Barnhart KT / 2003 / The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens / Obstet Gynecol 101 : 778 ~ 784
Centers for Disease Control and Prevention / 2012 / Ectopic pregnancy mortality: Florida, 2009-2010 / MMWR Morb Mortal Wkly Rep 61 : 106 ~ 109
Gamzu R / 2002 / Efficacy of methotrexate treatment in extrauterine pregnancies defined by stable or increasing human chorionic gonadotropin concentrations / Fertil Steril 7
Guvendag Guven ES / 2010 / Comparison of single and multiple dose methotrexate therapy for unruptured tubal ectopic pregnancy: a prospective randomized study / Acta Obstet Gy
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