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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1,033 - 1,040 (8page)
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Purpose Both genetic and lifestyle factors contribute to the risk of colorectal cancer, but each individual factor has a limited effect. Therefore, we investigated the association between colorectal cancer and the combined effects of genetic factors or/and lifestyle risk factors. Materials and Methods In a case-control study of 632 colorectal cancer patients and 1,295 healthy controls, we quantified the genetic risk score for colorectal cancer using 13 polymorphisms. Furthermore, we determined a combined lifestyle risk score including obesity, physical activity, smoking, alcohol consumption, and dietary inflammatory index. The associations between colorectal cancer and risk score using these factors were examined using a logistic regression model. Results Higher genetic risk scores were associated with an increased risk of colorectal cancer (odds ratio [OR], 2.57; 95% confidence interval [CI], 1.89 to 3.49 for the highest tertile vs. lowest tertile). Among the modifiable factors, previous body mass index, physical inactivity, heavy alcohol consumption, and a high inflammatory diet were associated with an increased risk of colorectal cancer. A higher lifestyle risk score was associated with an increased risk of colorectal cancer (OR, 5.82; 95% CI, 4.02 to 8.44 for the highest tertile vs. lowest tertile). This association was similar in each genetic risk category. Conclusion Adherence to a healthy lifestyle is associated with a substantially reduced risk of colorectal cancer regardless of individuals’ genetic risk.
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참고문헌 (30)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Lichtenstein P / 2000 / Environmental and heritable factors in the causation of cancer : analyses of cohorts of twins from Sweden, Denmark, and Finland / N Engl J Med 343:78~85
Jung KJ / 2015 / A colorectal cancer prediction model using traditional and genetic risk scores in Koreans / BMC Genet 16:49
Zhang B / 2014 / Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk / Nat Genet 46:533~542
Jia WH / 2013 / Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer / Nat Genet 45:191~196
Lichtenstein P / 2000 / Environmental and heritable factors in the causation of cancer : analyses of cohorts of twins from Sweden, Denmark, and Finland / N Engl J Med 343:78~85
Jung KJ / 2015 / A colorectal cancer prediction model using traditional and genetic risk scores in Koreans / BMC Genet 16:49
Zhang B / 2014 / Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk / Nat Genet 46:533~542
Jia WH / 2013 / Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer / Nat Genet 45:191~196
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