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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제24권 제1호
- 발행연도
- 2019.1
- 수록면
- 41 - 48 (8page)
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Purpose: This study was conducted to investigate the distributions of the triglyceride (TG) to high-density lipoprotein-cholesterol (HDL-C) ratio and total cholesterol (TC) to HDL-C ratio, and to explore their usefulness as markers of metabolic syndrome (MetS) in Korean adolescents. Methods: We obtained data for 2,721 adolescents (1,436 boys and 1,285 girls) aged 10–18 years who participated in the Korean National Health and Nutrition Examination Surveys from 2008 to 2010. International Diabetes Federation criteria were used to define MetS. Results: : There were no significant gender-related differences in TG/HDL-C or TC/ HDL-C ratios. These lipid ratios showed significant associations with homeostatic model assessment for insulin resistance (HOMA-IR) and waist circumference. Areas under the receiver operating characteristic curve to identify MetS were 0.947 for TG/HDL-C and 0.924 for TC/HDL-C, which were higher than that of HOMA-IR (0.822). Optimal cutoff values (sensitivity, specificity) of TG/HDL-C and TC/HDL-C ratios for MetS prediction were 3.3 (85.7%, 89.9%), and 3.8 (92.9%, 82.8%), respectively. Odds ratio (OR; 95% confidence intervals [CIs]) for MetS in adolescents with TC/HDL-C ratio above the cutoff value was 14.8 (2.8–77.4), while that for TG/HDL-C ratio about the cutoff value was 30.6 (6.0–157.6). In adolescents who had both lipid ratios above the cutoff values, the OR (95% CI) for MetS was 36.2 (7.2–186.2). Conclusion: TG/HDL-C and TC/HDL-C ratios are useful markers of metabolic syndrome with high predictive value in Korean adolescents.
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참고문헌 (30)
참고문헌 신청
Park MJ / 2009 / Prevalence and trends of metabolic syndrome among Korean adolescents:from the Korean NHANES survey, 1998-2005 / J Pediatr 155:529~534
Esser N / 2014 / Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes / Diabetes Res Clin Pract 105:141~150
Morrison JA / 2008 / Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later / J Pediatr 152:201~206
Cook S / 2003 / Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994 / Arch Pediatr Adolesc Med 157:821~827
Zimmet P / 2007 / The metabolic syndrome in children and adolescents / Lancet 369:2059~2061
Esser N / 2014 / Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes / Diabetes Res Clin Pract 105:141~150
Morrison JA / 2008 / Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later / J Pediatr 152:201~206
Cook S / 2003 / Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994 / Arch Pediatr Adolesc Med 157:821~827
Zimmet P / 2007 / The metabolic syndrome in children and adolescents / Lancet 369:2059~2061
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