지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
High blood pressure (HTN) is a condition in which blood pressure is kept higher than normal. Blood pressure trait measures systolic blood pressure (SBP) which is the highest pressure and diastolic blood pressure (DBP) which is the lowest blood pressure. Pulse pressure (PP) is the difference between systolic and diastolic blood pressure. Hypertension is known as a disease caused by the interaction of the environment and genetic factors. To date, studies have been conducted to find genes associated with hypertension. Genome-Wide Association Study (GWAS) analysis using European data from the UK Biobank reported new 535 loci were associated with blood pressure trait. Among them, 12 genes have been reported to have a significant correlation with SBP, DBP and PP. In the study, 12 genes polymorphisms were extracted based on KARE (Korean association resource) and then we performed linear regression of blood pressure trait. As a result, 6 SNPs of the 3 genes (rs12355413 and rs11006736 of ARMC4, rs2290883, rs2290884 and rs11039014 of LRP4, rs7234941 of BCL2) showed statistically significant correlation (P<0.05) with blood pressure trait. Of the 3 genes, 6 SNPs in 2 genes (rs9651357, rs12355413, rs11006736, rs1889522 of ARMC4 and rs4987774, rs7234941 of BCL2) showed significant correlation with hypertension. These results suggest that genetic polymorphisms of ARMC4, LRP4 and BCL2 genes are associated with blood pressure traits and hypertension in Korean population. Moreover, we expected to help understand the pathogenesis of hypertension.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (33)
참고문헌 신청
Barrett JC / 2005 / Haploview : analysis and visualization of LD and haplotype maps / Bioinformatics 21:263~265
Chen SZ / 2016 / CAMK4 gene variation is associated with hypertension in a uygur population / Genetics and Molecular Research 15
Cho YS / 2009 / A large-scale genome-wide association study of asian populations uncovers genetic factors influencing eight quantitative traits / Nature Genetics 41:527~534
Dlamini Z / 2015 / Abnormalities in alternative splicing of apoptotic genes and cardiovascular diseases / International Journal of Molecular Sciences 16:27171~27190
Dries DL / 2005 / Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension / Circulation 112:2403~2410
Chen SZ / 2016 / CAMK4 gene variation is associated with hypertension in a uygur population / Genetics and Molecular Research 15
Cho YS / 2009 / A large-scale genome-wide association study of asian populations uncovers genetic factors influencing eight quantitative traits / Nature Genetics 41:527~534
Dlamini Z / 2015 / Abnormalities in alternative splicing of apoptotic genes and cardiovascular diseases / International Journal of Molecular Sciences 16:27171~27190
Dries DL / 2005 / Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension / Circulation 112:2403~2410
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UCI(KEPA) : I410-ECN-0101-2020-510-000511943