지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 117 - 124 (8page)
이용수
초록· 키워드
오류제보하기
Objective : Broccoli is edible green plant that has a wide variety of health benefits including cancer prevention and cholesterol reduction. However, leaves of broccoli are not eaten and are mostly left as waste. This study was conducted to evaluate the effects of the broccoli leaf extract (BLE) on prostaglandin E2 (PGE2) production related to nuclear factor kappa B (NF-κB) signaling in lipopolysaccharide (LPS)-activated macrophages. Methods : BLE was prepared by extracting dried leaf with ethanol. Cell viability was determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. PGE2 and inflammatory cytokines were detected by enzyme-linked immunosorbent assay (ELISA). Expression level of each protein was monitored by Western blot analysis. Results : In LPS-activated Raw264.7 cells, PGE2 release into culture medium was dramatically enhanced compared to control cells. However, increased PGE2 was attenuated dose-dependently by treatment with BLE. Inhibition of PGE2 production by BLE was due to the suppression of cyclooxygenase-2 (COX-2) expression determined by Western blot analysis. BLE also inhibited the production of inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Inhibition at PGE2 and cytokine was mediated from inhibition of nuclear translocation of NF-κB due to the repression of inhibitory kappa B alpha (IκBα) phosphorylation and degradation. Conclusion : This study showed that BLE exerted inhibitory activities against PGE2, which is critical for the initiation and resolution of inflammatory responses, and that inhibition of PGE2 was mediated by suppression of NF-κB signaling. These results suggest that the waste broccoli leaves could be used for controlling inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
LPS로 유도한 염증반응에서 해죽순의 항염증 효과
대한본초학회지(본초분과학회지)
2016 .01
-
죽엽 열수추출물의 염증억제 효과
대한한의학방제학회지
2016 .01
-
Controls of Nuclear Factor-Kappa B Signaling Activity by 5’-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells
International Neurourology Journal
2016 .01
-
Tolfenamic Acid Suppresses Inflammatory Stimuli-Mediated Activation of NF-κB Signaling
Biomolecules & Therapeutics(구 응용약물학회지)
2015 .01
-
Differential Regulation of NF-κB Signaling during Human Cytomegalovirus Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .06
-
Wnt-C59 inhibits proinflammatory cytokine expression by reducing the interaction between β-catenin and NF-κB in LPS-stimulated epithelial and macrophage cells
The Korean Journal of Physiology & Pharmacology
2021 .01
-
RAW 264.7 세포에서 음양곽(淫羊藿) 물 추출물의 nuclear factor-κB 억제를 통한 항염증 효과
대한본초학회지(본초분과학회지)
2018 .01
-
NF-κB 억제를 통한 대회향(大茴香)의 항염증효능
대한한의학방제학회지
2016 .01
-
Expression of NF2 Modulates the Progression of BRAFV600E Mutated Thyroid Cancer Cells
Endocrinology and Metabolism
2019 .01
-
Viridicatol from Marine-derived Fungal Strain Penicillium sp. SF-5295 Exerts Anti-inflammatory Effects through Inhibiting NF-κB Signaling Pathway on Lipopolysaccharide-induced RAW264.7 and BV2 Cells
Natural Product Sciences
2015 .12
-
제1형 신경섬유종증 가족에서 발견된 NF1 유전자 변이와 임상양상
대한내과학회지
2016 .01
-
H₂O₂ 처리된 LLC-PK₁세포에서 Redox Status 및 NF-κB Signaling에 대한 夏枯草의 효과
동의생리병리학회지
2016 .08
-
Perceptions of a night float system for intern doctors in an internal medicine program: an Asian perspective
Korean Journal of Medical Education
2019 .01
-
대두, 홍삼, 진피로 구성된 발효 추출물의 항염증 효능에 관한 연구
대한본초학회지(본초분과학회지)
2015 .01
-
槐花散의 NF-κB 기전을 통한 항염증 효과 연구
한방안이비인후피부과학회지
2023 .02
-
Arsenic Trioxide Induces Apoptosis and Incapacitates Proliferation and Invasive Properties of U87MG Glioblastoma Cells through a Possible NF-κB-Mediated Mechanism
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
H<sub>2</sub>O<sub>2</sub> 처리된 LLC-PK₁세포에서 Redox Status 및 NF-κB Signaling에 대한 하고초(夏枯草)의 효과
동의생리병리학회지
2016 .01
-
Anti-inflammatory Effects of Ethanol Extract of Korean Medicinal Plants at Hwaak Mountain in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
Early-Onset Breast Cancer in a Family with Neurofibromatosis Type 1 Associated with a Germline Mutation in BRCA1
Journal of Breast Cancer
2015 .01
-
만성 저온 스트레스 동물모델에서의 황련(黃連)의 항염증 효능 연구
대한본초학회지(본초분과학회지)
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0