Current Drugs and Drug Targets in Non-Small Cell Lung Cancer: Limitations and Opportunities

Daga, Aditi; Ansari, Afzal; Patel, Shanaya; Mirza, Sheefa; Rawal, Rakesh; Umrania, Valentina

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자료유형: 학술저널

저자정보: Daga, Aditi (Department of Microbiology, MVM Science College, Saurashtra University) Ansari, Afzal (BIT virtual Institute of Bioinformatics [GCRI Node], GSBTM) Patel, Shanaya (The Gujarat Cancer & Research Institute) Mirza, Sheefa (The Gujarat Cancer & Research Institute) Rawal, Rakesh (The Gujarat Cancer & Research Institute) Umrania, Valentina (Department of Microbiology, MVM Science College, Saurashtra University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제10호

발행연도: 2015.1

수록면: 4,147 - 4,156 (10page)

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Lung cancer is a serious health problem and leading cause of death worldwide due to its high incidence and mortality. More than 80% of lung cancers feature a non-small cell histology. Over few decades, systemic chemotherapy and surgery are the only treatment options in this type of tumor but due to their limited efficacy and overall poor survival of patients, there is an urge to develop newer therapeutic strategies which circumvent the problems. Enhanced knowledge of translational science and molecular biology have revealed that lung tumors carry diverse driver gene mutations and adopt different intracellular pathways leading to carcinogenesis. Hence, the development of targeted agents against molecular subgroups harboring critical mutations is an attractive approach for therapeutic treatment. Targeted therapies are clearly more preferred nowadays over systemic therapies because they target tumor specific molecules resulting with enhanced activity and reduced toxicity to normal tissues. Thus, this review encompasses comprehensive updates on targeted therapies for the driver mutations in non-small cell lung cancer (NSCLC) and the potential challenges of acquired drug resistance faced i n the field of targeted therapy along with the imminent newer treatment modalities against lung cancer.

#Lung cancer #driver mutation #translocation #drug target #targeted therapy #acquired resistance #NSCLC

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