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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 341 - 348 (8page)
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The targeted nuclease clustered, regularly interspaced short palindromic repeats/CRISPR-associated proteins (CRISPR/Cas) system has recently emerged as a prominent gene manipulation method. Because of its ease in programming targeted DNA/protein binding through RNA in a vast range of organisms, this prokaryotic defense system is a versatile tool with many applications in the research field as well as high potential in agricultural and clinical improvements. This review will present a brief history that led to its discovery and adaptation. We also present some of its restrictions, and modifications that have been performed to overcome such restrictions, focusing specifically on the most common CRISPR/Cas9 mediated non-homologous end joint repair.
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등록된 정보가 없습니다.
참고문헌 (86)
참고문헌 신청
Cyranoski D / 2019 / The CRISPR-baby scandal : what's next for human gene-editing / Nature 566:440~442
El-Mounadi K / 2020 / Principles, Applications, and Biosafety of Plant Genome Editing Using CRISPR-Cas9 / Front Plant Sci 11:56
Lassoued R / 2019 / Benefits of genome-edited crops : expert opinion / Transgenic Res 28:247~256
Smithies O / 1985 / Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination / Nature 317:230~234
Bollag RJ / 1989 / Homologous recombination in mammalian cells / Annu Rev Genet 23:199~225
El-Mounadi K / 2020 / Principles, Applications, and Biosafety of Plant Genome Editing Using CRISPR-Cas9 / Front Plant Sci 11:56
Lassoued R / 2019 / Benefits of genome-edited crops : expert opinion / Transgenic Res 28:247~256
Smithies O / 1985 / Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination / Nature 317:230~234
Bollag RJ / 1989 / Homologous recombination in mammalian cells / Annu Rev Genet 23:199~225
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Development of the CRISPR-Cas Systems in Cyanobacteria for CO₂ Utilization
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