메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Ahn Young-Hwan (Departments of Gastroenterology Ajou Research Institute for Innovative Medicine Ajou University Sch) Lee Heirim (Departments of Biomedical Informatics Ajou Research Institute for Innovative Medicine Ajou Universi) Kim Do Young (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.) Lee Hye Won (Department of Internal Medicine Yonsei University College of Medicine Seoul KoreaYonsei Liver Cente) Yu Su Jong (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Cho Young Youn (Department of Internal Medicine and Liver Research Institute Seoul National University College of M) Jang Jeong Won (Department of Internal Medicine College of Medicine The Catholic University of Korea Seoul Korea) Jang Byoung Kuk (Department of Internal Medicine Keimyung University School of Medicine Daegu Korea.) Kim Chang Wook (Division of Hepatology Department of Internal Medicine Uijeongbu St. Mary's Hospital College of Med) Kim Hee Yeon (Division of Hepatology Department of Internal Medicine Uijeongbu St. Mary's Hospital College of Med) Park Hana (Department of Internal Medicine CHA Bundang Medical Center CHA University Seongnam Korea) Cho Hyo Jung (Departments of Gastroenterology Ajou Research Institute for Innovative Medicine Ajou University Sch) Park Bumhee (Departments of Biomedical Informatics Ajou Research Institute for Innovative Medicine Ajou Universi) Kim Soon Sun (Departments of Gastroenterology Ajou Research Institute for Innovative Medicine Ajou University Sch) Cheong Jae Youn (Departments of Gastroenterology Ajou Research Institute for Innovative Medicine Ajou University Sch)
저널정보
거트앤리버 발행위원회 Gut and Liver Gut and Liver 제15권 제3호
발행연도
2021.1
수록면
410 - 419 (10page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background/Aims: This study was performed to evaluate the efficacy of direct-acting antivirals (DAAs) in Korean patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) and to investigate the risk factors associated with HCC recurrence. Methods: A total of 100 patients with HCV-related HCC, who were treated with DAAs between May 2015 and December 2016, were recruited from seven university hospitals in Korea. Claim data of 526 patients with HCC obtained from the Health Insurance Review and Assessment Service in South Korea were used for external validation of the results. Results: Among the 100 patients, 88% achieved a sustained virological response (SVR) 12 weeks after the end of DAA therapy (SVR12), and 37% experienced HCC recurrence after DAA therapy. Short last HCC treatment durability (<12 months) before DAA commencement was independently associated with HCC recurrence (hazard ratio [HR], 2.89; p=0.011). In the nationwide validation cohort, 20.3% of the patients experienced HCC recurrence. The last HCC treatment with a noncurative method, a short last HCC treatment durability (<12 months), and a longer total duration of HCC treatment (≥18 months) were independently related with HCC recurrence (HR 3.73, p<0.001; HR 3.34, p<0.001; and HR 1.74, p=0.006; respectively). Conclusions: DAA therapy showed an acceptable SVR12 rate in patients with HCV-related HCC. Short last HCC treatment durability (<12 months) was associated with HCC recurrence after DAA therapy. This finding suggests that the last HCC treatment durability is an important predictor of HCC recurrence after DAA therapy.
#Carcinoma #hepatocellular #Antiviral agents #Risk factors #Hepatitis C #chronic #Recurrence

목차

등록된 정보가 없습니다.

참고문헌 (32)

참고문헌 신청
El-Serag HB / 2002 / Hepatocellular carcinoma : an epidemiologic view / J Clin Gastroenterol 35(5 Suppl 2):S72~S78 google schola Bray F / 2018 / Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185countries / CA Cancer J Clin 68:394~424 google schola Zeuzem S / 2015 / Grazoprevir-elbasvir combination therapy for treatment-naive cirrhotic and noncirrhotic patients with chronic hepatitis C virus genotype 1, 4, or 6 infection : a randomized trial / Ann Intern Med 163:1~13 google schola Kowdley KV / 2017 / Eight weeks of ledipasvir/sofosbuvir is effective for selected patients with genotype 1 hepatitis C virus infection / Hepatology 65:1094~1103 google schola Pol S / 2017 / Safety and efficacy of daclatasvir-sofosbuvir in HCV genotype 1-mono-infected patients / J Hepatol 66:39~47 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0