지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 30 - 37 (8page)
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Background/Aims: The National Liver Cancer Screening Program (NLCSP) has been implemented for the past 15 years in Korea. However, the actual clinical experience in Korea is inconsistent with the expectations of the hepatocellular carcinoma (HCC) surveillance program. To evaluate the actual clinical situation of HCC diagnoses, we investigated disease severity in patients with HCC and the diagnostic environment. Methods: From January 2011 to December 2015, all patients who were diagnosed with HCC in a single secondary hospital in Daejeon city were retrospectively enrolled in this study. Severity of HCC was evaluated according to the Barcelona Clinic Liver Cancer (BCLC) staging system. Results: Over the course of 5 years, 298 participants were enrolled. The mean age of participants was 64.0 years. Positive hepatitis B surface antigen was confirmed in 134 patients (45.0%), 35 patients (11.7%) tested positive for anti-hepatitis C virus antibody, and 93 patients (32.2%) had more than 40 g/day of alcohol consumption. The proportions of patients according to BCLC stages were as follows: BCLC-0, 28 patients (9.4%); BCLC-A, 42 patients (14.1%); BCLC-B, 26 patients (8.7%); BCLC-C, 134 patients (45.0%); and BCLC-D, 68 patients (22.8%). The diagnostic environments were as follows: 19 patients were in the NLCSP group (6.4%), 114 in the group with presenting signs (38.3%), 110 in the regular outpatient care group (36.9%), and 55 patients in the incidental diagnosis group (18.5%). Conclusions: Most patients (67.8%) had advanced stage HCC at diagnosis, and curative treatment was not indicated due to the severity disease. Thus, the actual situation is far worse than the theoretical expectation of HCC surveillance, suggesting that many high-risk patients for HCC are missed in surveillance.
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참고문헌 (25)
참고문헌 신청
Zhang BH / 2004 / Randomized controlled trial of screening for hepatocellular carcinoma / J Cancer Res Clin Oncol 130:417~422
Singal A / 2009 / Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis / Aliment Pharmacol Ther 30:37~47
Zhao C / 2016 / Hepatocellular carcinoma screening and surveillance: practice guidelines and real-life practice / J Clin Gastroenterol 50:120~133
Santi V / 2010 / Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival / J Hepatol 53:291~297
Bruix J / 2011 / Management of hepatocellular carcinoma: an update / Hepatology 53:1020~1022
Singal A / 2009 / Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis / Aliment Pharmacol Ther 30:37~47
Zhao C / 2016 / Hepatocellular carcinoma screening and surveillance: practice guidelines and real-life practice / J Clin Gastroenterol 50:120~133
Santi V / 2010 / Semiannual surveillance is superior to annual surveillance for the detection of early hepatocellular carcinoma and patient survival / J Hepatol 53:291~297
Bruix J / 2011 / Management of hepatocellular carcinoma: an update / Hepatology 53:1020~1022
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