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논문 기본 정보
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- 학술저널
- 저자정보
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- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.7 No.4
- 발행연도
- 2015.1
- 수록면
- 321 - 331 (11page)
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Immunoglobulin E (IgE) can be highly elevated in the airway mucosa independently of IgE serum levels and atopic status. Mostly, systemic markers are assessed to investigate inflammation in airway disease for research or clinical practice. A more accurate but more cumbersome approach to determine inflammation at the target organ would be to evaluate markers locally. We review evidence for local production of IgE in allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP). Diagnostic and therapeutic consequences in clinical practice are discussed. We describe that the airway mucosa has the intrinsic capability to produce IgE. Moreover, not only do IgE-positive B cells reside within the mucosa, but all tools are present locally for affinity maturation by somatic hypermutation (SHM), clonal expansion, and class switch recombination to IgE. Recognizing local IgE in the absence of systemic IgE has diagnostic and therapeutic consequences. Therefore, we emphasize the importance of local IgE in patients with a history of AR or CRSwNP.
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참고문헌 (39)
참고문헌 신청
Gevaert P / 2013 / Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps / Allergy 68:55~63
Durham SR / 1997 / Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid / Eur J Immunol 27:2899~2906
Cameron L / 2003 / S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination / J Immunol 171:3816~3822
Takhar P / 2005 / Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis / J Immunol 174:5024~5032
Van Zele T / 2006 / Differentiation of chronic sinus diseases by measurement of inflammatory mediators / Allergy 61:1280~1289
Durham SR / 1997 / Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid / Eur J Immunol 27:2899~2906
Cameron L / 2003 / S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombination / J Immunol 171:3816~3822
Takhar P / 2005 / Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis / J Immunol 174:5024~5032
Van Zele T / 2006 / Differentiation of chronic sinus diseases by measurement of inflammatory mediators / Allergy 61:1280~1289
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