지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.12
- 수록면
- 1,078 - 1,087 (10page)
- DOI
- 10.3349/ymj.2022.0298
이용수
초록· 키워드
오류제보하기
Purpose: The association between reactogenicity and immunogenicity of the ChAdOx1 nCOV-19 is controversial. We aimed to evaluate this association among South Korean healthcare workers (HCWs).
Materials and Methods: Participants received two doses of the ChAdOx1vaccine 12 weeks apart. Blood samples were tested for anti-severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) spike protein receptor binding domain antibodies about 2 months after the first and second doses using the Elecsys Anti-SARS-CoV-2 S assay kits. Adverse events were noted using an online self-reporting questionnaire.
Results: Among the 232 HCWs, pain (85.78% after the first dose vs. 58.62% after the second dose, p<0.001) was the most prominent local reaction, and myalgia or fatigue (84.05% vs. 53.02%, p<0.001) was the most prominent systemic reaction. The frequency of all adverse events was significantly reduced after the second dose. After the first dose, the anti-SARS-CoV-2 S showed significantly higher titer in the group with swelling, itching, fever, and nausea. Also, the anti-SARS-CoV-2 S titer significantly increased as the grade of fever (p=0.007) and duration of fever (p=0.026) increased; however, there was no significant correlation between immunogenicity and adverse event after the second dose. The group with pain after the first dose showed a greater increase in the anti-SARS-CoV-2 S difference between the second and first doses compared to the group without pain (542.2 U/mL vs. 363.8 U/mL, p=0.037).
Conclusion: The frequency of adverse events occurring after the first dose of the ChAdOx1 was significantly reduced after the second dose. Interestingly, the elevation of anti-SARS-CoV-2 S titer was significantly increased in the group with pain after the first dose.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Anti-S1/RBD-Specific Antibody Formation After SARS-CoV-2 Vaccination in Elderly Rheumatoid Arthritis Patients: Single-Center Prospective Observational Study
Journal of Korean Medical Science
2023 .04
-
Anti-SARS-CoV-2 spike antibody response to the third dose of BNT162b2 mRNA COVID-19 vaccine and associated factors in Japanese hemodialysis patients
Kidney Research and Clinical Practice
2024 .05
-
Changes in SARS-CoV-2 antibody titers 6 months after the booster dose of BNT162b2 COVID-19 vaccine among health care workers
Clinical and Experimental Vaccine Research
2023 .04
-
Survey of Adverse Events After The First Dose of The ChAdOx1 nCoV-19 Vaccine: A Single-Center Experience in Korea
Infection and Chemotherapy
2021 .09
-
Antibody Response Induced by Two Doses of ChAdOx1 nCoV-19, mRNA-1273, or BNT162b2 in Liver Transplant Recipients
Immune Network
2022 .06
-
Eight-Month Follow-up After the Third Dose of BNT162b2 Vaccine in Healthcare Workers: The Question of a Fourth Dose
Journal of Korean Medical Science
2023 .05
-
Strong SARS-CoV-2 Antibody Response After Booster Dose of BNT162b2 mRNA Vaccines in Uninfected Healthcare Workers
Journal of Korean Medical Science
2022 .05
-
Humoral Immune Response of Heterologous ChAdOx1 nCoV-19 and mRNA-1273 Prime-Boost Vaccination against SARS-CoV-2 Variants in Korea
Infection and Chemotherapy
2023 .03
-
Prevalence of SARS-CoV-2 Antibody in 2,935 Healthcare Workers at 6 Major Hospitals, Daegu, Korea
Journal of Korean Medical Science
2021 .11
-
Adverse Reactions of the Second Dose of the BNT162b2 mRNA COVID-19 Vaccine in Healthcare Workers in Korea
Journal of Korean Medical Science
2021 .01
-
Lessons Learned from SARS-CoV and MERS-CoV: Preparation for SARS-CoV-2 induced COVID-19
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2020 .06
-
SARS-CoV-2-Specific T Cell Responses in Patients with COVID-19 and Unexposed Individuals
Immune Network
2021 .02
-
Evaluation of Cellular Responses to ChAdOx1-nCoV-19 and BNT162b2 Vaccinations
Annals of Laboratory Medicine
2023 .05
-
Reactogenicity after the first and second doses of BNT162b2 mRNA coronavirus disease vaccine: a single-center study
Clinical and Experimental Vaccine Research
2021 .09
-
Comparison of Antibody and T Cell Responses Induced by Single Doses of ChAdOx1 nCoV-19 and BNT162b2 Vaccines
Immune Network
2021 .08
-
Virus Isolation from the First Patient with SARS-CoV-2 in Korea
Journal of Korean Medical Science
2020 .01
-
A Case Report of Immune Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
Journal of Korean Medical Science
2021 .11
-
SARS-CoV-2 Delta (B.1.617.2) Variant: A Unique T478K Mutation in Receptor Binding Motif (RBM) of Spike Gene
Immune Network
2021 .10
-
Immunogenicity of the ChAdOx1 nCoV-19 vaccine in patients with hematologic malignancies
Clinical and Experimental Vaccine Research
2023 .04
-
Immunogenicity of SARS-CoV-2 Vaccine in Kidney Transplant Recipients: A Cross-Sectional Study in Korea
Journal of Korean Medical Science
2023 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0