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This study was conducted to confirm the performance of the microRNA (miRNA) biomarker combination as a new breast cancer screening method in Korean women under the age of 50 with a high percentage of dense breasts. To determine the classification performance of a set of miRNA biomarkers (miR-1246, 202, 21, and 219B) useful for breast cancer screening, we determined whether there was a significant difference between the breast cancer and healthy control groups through box plots and the Mann? Whitney U-test, which was further examined in detail by age group. To verify the classification performance of the 4 miRNA bio marker set, 4 classification methods (logistic regression, random forest, XGBoost, and generalized linear model plus random forest) were applied, and 10-fold cross-validation was used as a validation method to improve performance stability. We confirmed that the best breast cancer detection performance was achievable in patients under 50 years of age when the set of 4 miRNAs were used.
Under the age of 50, the 4 miRNA biomarkers showed the highest performance with a sensitivity of 85.29%, specificity of 93.33%, and area under the curve (AUC) of 0.961. Examining the results of 4 miRNA biomarkers was found to be an effective strategy for diagnosing breast cancer in Korean women under 50 years of age with dense breasts, and hence has the potential as a new breast cancer screening tool. Further validation in an appropriate screening population with large-scale clinical trials is required.
Key Words MicroRNA, Breast cancer, Screening, Dense breast, Korean women under the age of 50
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참고문헌 (30)
참고문헌 신청
홍세리 / 2020 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2017 / Cancer Research and Treatment 52(2):335~350
정규원 / 2019 / Prediction of Cancer Incidence and Mortality in Korea, 2019 / Cancer Research and Treatment 51(2):431~437
이주은 / 2018 / Projection of Breast Cancer Burden due to Reproductive/Lifestyle Changes in Korean Women (2013-2030) Using an Age-Period-Cohort Model / Cancer Research and Treatment 50(4):1388~1395
Yoo KY / 2008 / Cancer control activities in the Republic of Korea / Jpn J Clin Oncol 38:327~333
이은혜 / 2015 / 유방암 검진 권고안 개정안 / 대한의사협회지 58(5):408~419
정규원 / 2019 / Prediction of Cancer Incidence and Mortality in Korea, 2019 / Cancer Research and Treatment 51(2):431~437
이주은 / 2018 / Projection of Breast Cancer Burden due to Reproductive/Lifestyle Changes in Korean Women (2013-2030) Using an Age-Period-Cohort Model / Cancer Research and Treatment 50(4):1388~1395
Yoo KY / 2008 / Cancer control activities in the Republic of Korea / Jpn J Clin Oncol 38:327~333
이은혜 / 2015 / 유방암 검진 권고안 개정안 / 대한의사협회지 58(5):408~419
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