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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 487 - 496 (10page)
- DOI
- 10.5021/ad.2021.33.6.487
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초록· 키워드
오류제보하기
Mycosis fungoides (MF) and Sezary syndrome (SS) are the most common subtypes of cutane- ous T-cell lymphomas (CTCLs). Most cases of MF display an indolent course during its early stage. However, in some patients, it can progress to the tumor stage with potential systematic involvement and a poor prognosis. SS is defined as an erythrodermic CTCL with leukemic involvements. The pathogenesis of MF and SS is still not fully understood, but recent data have found that the development of MF and SS is related to genetic alterations and possibly to environmental influences. In CTCL, many components interacting with tumor cells, such as tumor-associated macrophages, fibroblasts, dendritic cells, mast cells, and myeloid?derived suppressor cells, as well as with chemokines, cytokines and other key players, establish the tumor microenvironment (TME). In turn, the TME regulates tumor cell migration and pro- liferation directly and indirectly and may play a critical role in the progression of MF and SS. The TME of MF and SS appear to show features of a Th2 phenotype, thus dampening tumor- related immune responses. Recently, several studies have been published on the immunologi- cal characteristics of MF and SS, but a full understanding of the CTCL-related TME remains to be determined. This review focuses on the role of the TME in MF and SS, aiming to further demonstrate the pathogenesis of the disease and to provide new ideas for potential treatments targeted at the microenvironment components of the tumor.
목차
등록된 정보가 없습니다.
참고문헌 (72)
참고문헌 신청
Willemze R / 2019 / The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas / Blood 133:1703~1714
Jawed SI / 2014 / Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers / J Am Acad Dermatol 70:205
Sarantopoulos GP / 2013 / Mimics of cutaneous lymphoma: report of the 2011Society for Hematopathology/European Association for Haematopathology workshop / Am J Clin Pathol 139:536~551
van Doorn R / 2009 / Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome / Blood 113:127~136
McGirt LY / 2015 / Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides / Blood 126:508~519
Jawed SI / 2014 / Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers / J Am Acad Dermatol 70:205
Sarantopoulos GP / 2013 / Mimics of cutaneous lymphoma: report of the 2011Society for Hematopathology/European Association for Haematopathology workshop / Am J Clin Pathol 139:536~551
van Doorn R / 2009 / Oncogenomic analysis of mycosis fungoides reveals major differences with Sezary syndrome / Blood 113:127~136
McGirt LY / 2015 / Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides / Blood 126:508~519
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