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논문 기본 정보

자료유형
학술저널
저자정보
Abdulwahab A Alshahrani (University of Ulsan College of Medicine) Shin Hwang (University of Ulsan College of Medicine) Gi-Won Song (University of Ulsan College of Medicine) Deok-Bog Moon (University of Ulsan College of Medicine) Dong-Hwan Jung (University of Ulsan College of Medicine) Chul-Soo Ahn (University of Ulsan College of Medicine) Ki-Hun Kim (University of Ulsan College of Medicine) Tae-Yong Ha (University of Ulsan College of Medicine) Gil-Chun Park (University of Ulsan College of Medicine) Su-Min Ha (University of Ulsan College of Medicine) Yo-Han Park (Inje University) Sung-Gyu Lee (University of Ulsan College of Medicine)
저널정보
한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제22권 제2호
발행연도
2018.5
수록면
136 - 143 (8page)

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Recurrence of hepatocellular carcinoma (HCC) 10 years after liver transplantation (LT) is very rare. Here, we present two cases of peritoneal metastasis of HCC that occurred 10 and 12 years after LT. A 77-year-old male who had undergone deceased-donor LT 10 years earlier showed slow progressive elevation of tumor marker levels over 6 months. Close observation with frequent imaging studies and monthly tumor marker analyses revealed a solitary peritoneal seeding mass. Imaging studies revealed that the mass was highly likely to be metastatic HCC. After excision of the mass, all tumor markers returned to the normal range. Over past 10 months, the patient has received everolimus monotherapy and half-dose sorafenib, and has shown no evidence of HCC recurrence. In the second case, marginally elevated tumor marker levels were detected in a 65-year-old male who had undergone living-donor LT 12 years earlier. After observation for 3 months, follow-up studies revealed a peritoneal seeding mass. Thorough imaging studies revealed that the mass was highly likely to be metastatic HCC. Two mass lesions were excised, and the patient was administered low-dose calcineruin inhibitor, sirolimus, and full-dose sorafenib. Subsequently, the tumor marker levels increased again and growth of new peritoneal seeding nodules was observed; therefore, sorafenib was stopped after 2 years of administration. During 6 years since HCC recurrence diagnosis, the patient has experienced slowly growing tumors, but has been doing well. For very late peritoneal metastasis of HCC, the therapeutic modalities include surgical resection if possible, everolimus monotherapy, and long-term use of sorafenib.

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UCI(KEPA) : I410-ECN-0101-2018-514-002045696