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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제16권 제2호
- 발행연도
- 2015.1
- 수록면
- 47 - 52 (6page)
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Macrophages play an important role in both the innate and adaptive immune responses. These include phagocytosis, killing of microorganisms, antigen presentation, and induction of immune cytokines and antimicrobial genes. Macrophage activity is reported to be controlled by diverse exogenous antigenic or endogenous metabolic molecules, and the underlying mechanisms are well documented in human and mouse macrophage cells. Bacterial lipopolysaccharide (LPS) is known to be one of the most potent stimuli activating macrophages through the toll like receptor 4 (TLR4) signaling pathway. There are other antigenic molecules, such as muramyl dipeptide (MDP) and outer membrane protein A (OmpA), that are also known to activate immune cells. On the other hand, short chain fatty acids (SCFAs) such as acetate and butyrate are produced by gut microbiota and control host energy metabolism and signal transduction through GPR receptors. However, there are few studies demonstrating the effects of these molecules in macrophages from domestic animals, including domestic pigs. In this study, we attempted to characterize gene expression regulation in porcine macrophages (PoM2, Pig Monocytes clone 2) following treatment with LPS, MDP, OmpA, and two short chain fatty acids using porcine genome microarray and RT-PCR techniques. A number of novel porcine genes, including anti-microbial peptides and others, appeared to be regulated at the transcriptional level. Our study reports novel biomarkers such as SLC37A2, TMEN184C, and LEAP2 that are involved in the porcine immune response to bacterial antigen LPS and two short chain fatty acids.
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참고문헌 (21)
참고문헌 신청
Artis D / 2015 / The biology of innate lymphoid cells / Nature 517 : 293 ~ 301
Bain CC / 2014 / The monocyte-macrophage axis in the intestine / Cell Immunol 291 : 41 ~ 48
Bhowmick R / 2014 / Outer membrane protein A (OmpA) of Shigella flexneri 2a induces TLR2-mediated activation of B cells: involvement of protein tyrosine kinase, ERK and NF-ka
Bode JG / 2012 / The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis / Cell Signal 24 : 1185 ~ 1194
Duan Q / 2012 / The flagella of F18ab Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro / Vet Microbiol 160 : 132 ~ 140
Bain CC / 2014 / The monocyte-macrophage axis in the intestine / Cell Immunol 291 : 41 ~ 48
Bhowmick R / 2014 / Outer membrane protein A (OmpA) of Shigella flexneri 2a induces TLR2-mediated activation of B cells: involvement of protein tyrosine kinase, ERK and NF-ka
Bode JG / 2012 / The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis / Cell Signal 24 : 1185 ~ 1194
Duan Q / 2012 / The flagella of F18ab Escherichia coli is a virulence factor that contributes to infection in a IPEC-J2 cell model in vitro / Vet Microbiol 160 : 132 ~ 140
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