지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Intrathecal baclofen (ITB) therapy has been proven to reduce severe spasticity in cerebral palsy (CP). However, few results reported the objective gait pattern change after ITB bolus injection in adult ambulatory CP. We therefore evaluated observational and kinematic gait patterns at different ITB bolus injection doses. We performed a test trial of 3-day ITB bolus injections at doses of 12.5 μg, 25 μg, and 50 μg in ambulatory CP. We evaluated modified Ashworth scale, visual analogue scale, observational gait scale, and kinematic gait analysis after ITB bolus injection. Intrathecal administration of low-dose baclofen 25 μg was successfully used not only for the treatment of spasticity but also for the treatment of gait disturbance, whereas the higher dose baclofen 50 μg induced foot drop and deteriorated gait pattern. We experienced dose-dependent changes in gait pattern confirmed by the observational and kinematic gait assessments after ITB bolus injection in adult ambulatory CP.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Bleyenheuft C / 2007 / Experience with external pump trial prior to implantation for intrathecal baclofen in ambulatory patients with spastic cerebral palsy / Clin Neurophysi
Boyd RN / 1999 / Objective measurement of clinical findings in the use of botulinum toxin type A for the management of children with cerebral palsy / Eur J Neurol 6 (supple 4
Horn TS / 2010 / Effect of intrathecal baclofen bolus injection on lower extremity joint range of motion during gait in patients with acquired brain injury / Arch Phys Med Re
Hoving MA / 2009 / Safety and one-year efficacy of intrathecal baclofen therapy in children with intractable spastic cerebral palsy / Eur J Paediatr Neurol 13 : 247 ~ 256
Jasmin L / 2003 / Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex / Nature 424 : 316 ~ 320
Boyd RN / 1999 / Objective measurement of clinical findings in the use of botulinum toxin type A for the management of children with cerebral palsy / Eur J Neurol 6 (supple 4
Horn TS / 2010 / Effect of intrathecal baclofen bolus injection on lower extremity joint range of motion during gait in patients with acquired brain injury / Arch Phys Med Re
Hoving MA / 2009 / Safety and one-year efficacy of intrathecal baclofen therapy in children with intractable spastic cerebral palsy / Eur J Paediatr Neurol 13 : 247 ~ 256
Jasmin L / 2003 / Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex / Nature 424 : 316 ~ 320
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