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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제4호
- 발행연도
- 2018.1
- 수록면
- 527 - 533 (7page)
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This study compared the radioprotective effects of high-molecular-weight poly-gammaglutamate (γ-PGA, average molecular mass 3,000 kDa) and a reduced form of glutathione (GSH, a known radioprotector) on calf thymus DNA damage. The radiation-induced DNA damage was measured on the basis of the decreased fluorescence intensity after binding the DNA with ethidium bromide. All the experiments used 60Co gamma radiation at 1,252 Gy, representing 50% DNA damage. When increasing the concentration of γ-PGA from 0.33 to 1.65 μM, the DNA protection from radiation-induced damage also increased, with a maximum of 87% protection. Meanwhile, the maximal DNA protection when increasing the concentration of GSH was only 70%. Therefore, γ-PGA exhibited significant radioprotective effects against gamma irradiation.
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참고문헌 (34)
참고문헌 신청
Saenger EL / 1980 / Manual on early medical treatment of possible radiation injury / Med. Phys. 7:82~82
Ramalho AT / 1991 / The fate of chromosomal aberrations in 137Cs-exposed individuals in the Goiania radiation accident / Health Phys. 60:67~70
Rosen EM / 2015 / New approaches to radiation protection / Front. Oncol. 4:381
Maier P / 2014 / Radioprotection of normal tissue cells / Strahlenther. Onkol. 190:745~752
Johnke RM / 2014 / Radioprotective agents for radiation therapy: future trends / Future Oncol. 10:2345~2357
Ramalho AT / 1991 / The fate of chromosomal aberrations in 137Cs-exposed individuals in the Goiania radiation accident / Health Phys. 60:67~70
Rosen EM / 2015 / New approaches to radiation protection / Front. Oncol. 4:381
Maier P / 2014 / Radioprotection of normal tissue cells / Strahlenther. Onkol. 190:745~752
Johnke RM / 2014 / Radioprotective agents for radiation therapy: future trends / Future Oncol. 10:2345~2357
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