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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 59 - 69 (11page)
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초록· 키워드
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The ability to read, write, and edit genomic information in livingorganisms can have a profound impact on research, health,economic, and environmental issues. The CRISPR/Cas system,recently discovered as an adaptive immune system in prokaryotes,has revolutionized the ease and throughput of genomeediting in mammalian cells and has proved itself indispensableto the engineering of immune cells and identification of novelimmune mechanisms. In this review, we summarize the CRISPR/Cas9 system and the history of its discovery and optimization. We then focus on engineering T cells and other types ofimmune cells, with emphasis on therapeutic applications. Last,we describe the different modifications of Cas9 and theirrecent applications in the genome-wide screening of immunecells.
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참고문헌 (65)
참고문헌 신청
Mardis ER / 2017 / DNA sequencing technologies : 2006-2016 / Nat Protoc 12:213~218
Zhang W / 2020 / Synthetic genomes / Annu Rev Biochem 89:77~101
Pickar-Oliver A / 2019 / The next generation of CRISPR-Cas technologies and applications / Nat Rev Mol Cell Biol 20:490~507
Sander JD / 2014 / CRISPR-Cas systems for editing, regulating and targeting genomes / Nat Biotechnol 32:347~355
Anzalone AV / 2020 / Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors / Nat Biotechnol 38:824~844
Zhang W / 2020 / Synthetic genomes / Annu Rev Biochem 89:77~101
Pickar-Oliver A / 2019 / The next generation of CRISPR-Cas technologies and applications / Nat Rev Mol Cell Biol 20:490~507
Sander JD / 2014 / CRISPR-Cas systems for editing, regulating and targeting genomes / Nat Biotechnol 32:347~355
Anzalone AV / 2020 / Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors / Nat Biotechnol 38:824~844
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