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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 365 - 365 (1page)
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CRISPR/Cas9 system provides an efficient tool for genome engineering of Streptomyces, a prolific source of commercially valuable secondary metabolites. However, the application of CRISPR-Cas9 system to Streptomyces strains has been limited due to the toxicity associated with Cas9 protein, resulting in low transformation efficiency or failure of genome engineering. Here, we engineer the Cas9 gene promoter to optimize its expression with an aim to reduce toxicity while maintaining high engineering efficiency. Randomized Cas9 promoters were screened using our ^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10675056');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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