지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.8
- 수록면
- 437 - 449 (13page)
- DOI
- 10.7856/kjcls.2021.32.3.437
이용수
초록· 키워드
오류제보하기
Weissella koreensis (W. koreensis) DB1 with high-ornithine-producing capacity was isolated from kimchi and shows the anti-adipogenic activity via its production of ornithine. This study was carried out the effects of W. koreensis DB1 cell extracts on the inhibition of adipogenesis in 3T3-L1 cells. MTT results showed that 0-0.75 μg/mL W. koreensis DB1 cell extracts had no significant effect on cell vability. The cell extracts of W. koreensis DB1 at non-cytotoxic concentrations significantly suppressed the differentiated 3T3-L1 cells by decreasing triglyceride level and intracellular lipid accumulation compared to that associated with the untreated control group. The major transcriptional factors involved in adipocyte differentiation, such as peroxisome proliferator-activated receptorγ (PPARγ), CCAAT/enhancer-binding proteinα (C/EBPα), and sterol regulatory element-binding transcription factor-1c (SREBP-1c), were down-regulated by the cell extracts of W. koreensis DB1 treatments compared with the untreated control group. Furthermore, the expressions of lipogenesis-related enzymes including acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS) genes were also decreased by the cell extracts of W. koreensis DB1 treatment. Accordingly, these results indicate that the cell extracts of W. koreensis DB1 treatment inhibited the adipogenesis and lipogenesis of 3T3-L1 cells, suggesting a protective role in adipocyte differentiation.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 고찰
Ⅳ. 요약 및 결론
References
참고문헌 (69)
참고문헌 신청
Arena ME / 1999 / Arginine, citrulline and ornithine metabolism by lactic acid bacteria from wine / Int J Food Microbiol 52(3):155~161
CHO, YU RAN / 2007 / Production of γ-Aminobutyric Acid (GABA) by Lactobacillus buchneriIsolated from Kimchi and its Neuroprotective Effect on Neuronal Cells / Journal of Microbiology and Biotechnology 17(1):104~109
Choi HJ / 2002 / Weissella kimchii sp. nov., anovel lactic acid bacterium from kimchi / Int J Syst Evol Microbiol 52(Pt 2):507~511
최준혁 / 2013 / 참취(Aster scaber Thunb.) 추출물의 항산화 효과와 3T3-L1 지방전구세포에서의 지방분화 억제 효과 / 한국식품과학회지 45(3):356~363
Jaeryang Chu / 2019 / Inhibitory Effects of Lactobacillus plantarum Q180 on Lipid Accumulation in HepG2 Cells / 한국식품영양학회지 32(6):738~744
CHO, YU RAN / 2007 / Production of γ-Aminobutyric Acid (GABA) by Lactobacillus buchneriIsolated from Kimchi and its Neuroprotective Effect on Neuronal Cells / Journal of Microbiology and Biotechnology 17(1):104~109
Choi HJ / 2002 / Weissella kimchii sp. nov., anovel lactic acid bacterium from kimchi / Int J Syst Evol Microbiol 52(Pt 2):507~511
최준혁 / 2013 / 참취(Aster scaber Thunb.) 추출물의 항산화 효과와 3T3-L1 지방전구세포에서의 지방분화 억제 효과 / 한국식품과학회지 45(3):356~363
Jaeryang Chu / 2019 / Inhibitory Effects of Lactobacillus plantarum Q180 on Lipid Accumulation in HepG2 Cells / 한국식품영양학회지 32(6):738~744
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UCI(KEPA) : I410-ECN-0101-2021-590-002026441